Pfcrmp May Play a Key Role in Chloroquine Antimalarial Action and Resistance Development
نویسنده
چکیده
It was proposed earlier that Pfcrmp (Plasmodium falciparum chloroquine resistance marker protein) may be the chloroquine target protein in nucleus. In this communication, further evidence is presented to support the view that Pfcrmp may play a key role in chloroquine antimalarial actions as well as resistance development. PR EL IM IN A R Y R EP O R T
منابع مشابه
Introducing New Antimalarial Analogues of Chloroquine and Amodiaquine: A Narrative Review
Antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (CQ) and amodiaquine (AQ), have been used to prevent and treat malaria for many years. The importance of these drugs is related to their simple usage, high efficacy, affordability, and cost-effectiveness of their synthesis. In recent years, with the spread of parasite resistance to CQ and cross-resist...
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متن کاملNucleus may be the key site of chloroquine antimalarial action and resistance development.
The first proposed hypothesis about the mechanism of chloroquine (CQ) action on malaria parasites is DNA intercalation hypothesis which indicates that the site of CQ action is within nucleus. Later on the interest of research was shifted from nucleus to lysosome due to the report of CQ accumulation within lysosome. The current opinions about CQ action and resistance are mainly based on the resu...
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تاریخ انتشار 2009